�Atypical� atypical femur fractures and use of bisphosphonates
نویسندگان
چکیده
منابع مشابه
Bisphosphonates and Atypical Fractures of Femur
Bisphosphonates are the most widely prescribed medicines for the treatment of osteoporosis and have generally been regarded as well-tolerated and safe drugs. Since 2005, there have been numerous case reports about atypical fractures of the femur linked to long-term treatment of osteoporosis with bisphosphonates. Some attempts to characterize pathophysiology and epidemiology of these fractures h...
متن کاملAtypical femur fractures associated with use of bisphosphonates and denosumab.
progression [2]. In addition, the time gain is very large in cancers for which the response rate is used as a surrogate end point such as hematological malignancy [3]. Second, we are not discussing a surrogate end point for less serious disease like cardiovascular disease [4], but are discussing a surrogate end point supporting clinical trials of innovative new drugs of high unmet medical need ...
متن کاملBisphosphonates and atypical subtrochanteric fractures of the femur
OBJECTIVES Bisphosphonates are widely used as first-line treatment for primary and secondary prevention of fragility fractures. Whilst they have proved effective in this role, there is growing concern over their long-term use, with much evidence linking bisphosphonate-related suppression of bone remodelling to an increased risk of atypical subtrochanteric fractures of the femur (AFFs). The obje...
متن کاملAtypical femur fractures: 81 individual personal histories.
CONTEXT An online voluntary association of individuals who had incurred one or more atypical femur fractures (AFFs) while taking bisphosphonates for prevention or treatment of osteoporosis provided an opportunity to collect long-term histories. SETTING Individuals from a nationwide general community completed an anonymous survey documenting their history. PARTICIPANTS Within a larger cadre,...
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ژورنال
عنوان ژورنال: Clinical Cases in Mineral and Bone Metabolism
سال: 2016
ISSN: 1971-3266
DOI: 10.11138/ccmbm/2016.13.3.204